1258569_white_button_mushrooms 2  039mushroomsforsuppertoday
June 2011
Random Thoughts         Medical Mushrooms
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It is only in recent years that most American understand that there are other types of mushrooms than the white button ones pictured above on the left. Yet these 'everyday' mushrooms can act as aromatase inhibitors.  For those dealing with breast cancer you'll recognized the term.  This refers to the ability to block estrogen in the body.  From a 2001 study: "Because natural compounds such as flavones and isoflavones have been shown to be inhibitors of aromatase, it is thought that vegetables that contain these phytochemicals can inhibit aromatase activity and suppress breast cancer cell proliferation". Journal of Nutrition. 2001;131:3288-3293  
 

 Many of the different types of mushrooms help fight cancer - lots of research is done on them in Asia, with a few studies in the US as well.  Can anyone identify the mushroom type shown on the right?  This photo was donated by Marialuisa who lives in Spain.

One of the earliest conferences I ever attended was focused on what in the mid-1990's was ONLY called Alternative Medicine. At that meeting I saw exhibitors with mushroom-based cancer fighters.  I purchased Maitake D-fraction and ended up using it (taken internally) to reduce a chest wall (breast cancer) tumor. 

We have a good section on medicinal mushrooms but of course there are many more studies available:

http://annieappleseedproject.org/mushrooms.html 

We'll highlight some particularly interesting studies below (and some direct links).

Be well,

Ann Fonfa, President (volunteer)

PS I am off to Athens, Greece to display a poster on "Integrative Therapies for Unwanted (side) Effects of Conventional Treatment"  More on this next month
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An excellent resource everyone should know about is PubMed.gov - a site maintained by the National Library of Medicine and the National Institutes of Health. 
http://www.ncbi.nlm.nih.gov/pubmed/ 

A SEARCH using Mushrooms Cancer yielded 477 studies.

Here is one on "Maitake (D Fraction) Mushroom Extract Induces Apoptosis in Breast Cancer Cells by BAK-1 Gene ActivationJ Med Food. 2011 Jun;14(6):563-72. Epub 2011 Apr 11. 

Another study of interest, published in Japan "PSK decreased FOLFOX4-induced peripheral neuropathy and bone marrow suppression in patients with metastatic colorectal cancer"Gan To Kagaku Ryoho. 2011 May;38(5):797-801 concluded: "These results suggest that this combination therapy may be more effective than FOLFOX4 monotherapy when given over a longer period, with a lower incidence of adverse effects". 

And "Agaricus blazei Murill enhances doxorubicin-induced apoptosis in human hepatocellular carcinoma cells by NFκB-mediated increase of intracellular doxorubicin accumulation
Intl J Oncol. 2011 Feb;38(2):401-8. doi: 10.3892/ijo.2010.852. Epub 2010 Dec 3   (note that apoptosis means cancer cells die.  Doxorubicin is also known as adriamycin an anthracycline chemotherapy)acyknown tosis means cancer cels die 

 

AAPR Logo    http://www.annieappleseedproject.org
You can make any size donation using the Google donate (or PayPal) buttons on our front page - scroll down. We appreciate our support for our ALL-VOLUNTEER network.

When people donate to the Annie Appleseed Project, they often let us know why.  Here are three reasons we've heard:
"Just wanted to thank you and let you know I've been using your page (http://www.annieappleseedproject.org/gecali.html) for some research and Iit has proved very useful". 
"It is my pleasure to contribute to your beautiful and highly beneficial service you provide for people who have cancer, don't want to get cancer, and the caretakers.".
and "I continue to be influenced, personally and professionally, by what I saw and learned at the conference".  

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Why doesn't PubMed include studies from the peer-reviewed Journal of Orthomolecular Medicine?

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  "Orthomolecular medicine is defined as the therapeutic use of substances that occur naturally in the body. Originally defined in the context of treating and preventing psychiatric diseases, the intent of orthomolecular therapy is to provide the optimal molecular environment for the brain and other tissues by altering the intake of nutrients such as vitamins (and their metabolites), minerals, trace elements, macronutrients, as well as other naturally occurring metabolically active substances".

You can browse through 40 years of their papers:

http://orthomolecular.org/library/jom/index.shtml
 
From a recent study on Whey protein:

Effects of preoperative feeding with a whey protein plus carbohydrate drink on the acute phase response and insulin resistance. A randomized trial. 

Nutrition Journal 2011, 10:66 doi:10.1186/1475-2891-10-66

Prolonged pre-operative fasting increases insulin resistance and current evidence recommends carbohydrate (CHO) drinks 2 hours before surgery. Our hypothesis is that the addition of whey protein to a CHO-based drink not only reduces the inflammatory response but also diminish insulin resistance.

Conclusions: Shortening the pre-operative fasting using CHO and whey protein is safe and reduces insulin resistance and postoperative acute phase response in elective moderate operations.




Our 2012 Evidence-based Complementary and Alternative Cancer Therapies conference is set for March 1-3 in West Palm Beach.
We hope to have several panels on Insurance Reimbursement and CAM issues.  If you can recommend speakers, let us know how to reach them.

An Annie Appleseed Project West Coast conference is being planned for Fall 2012 around the San Francisco area.

Remember we respond to all emails so if you seek some specific information from our site, feel free to contact us.  We try to cover a broad array of issues for many cancer diagnoses.

Tel: (561) 749-0084
Fax: (561) 499-6424
Email: annieappleseedpr@aol.com
 




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