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March 2, 2012
Currents in Cell Medicine
Latest News and Research from the ICMS
Volume 2, Number 2

4th Annual International Congress for Regenerative and Cell-Based Medicine

On May 3rd, 2012, the global cell-medicine community will come together in Hollywood, Florida for the 4th Annual International Congress for Regenerative and Cell-Based Medicine. 


We invite all ICMS members and everyone interested in the field of stem cells to join us. We will be bringing together experts from around the world to give lectures on how stem cells are being used as a point-of-care therapy. In association with our partner, AMMG, we are pleased to present the only conference dedicated exclusively to stem cells in the practice of medicine.


For a full agenda, a complete list of faculty, and additional information about the conference, please visit the ICMS website


Register today, and join us and your colleagues in Hollywood on May 3rd.

Overview of the Regulations for the medical use of stem cells in Mexico 

Working in collaboration with SOMMER, our sister organization in Mexico, the ICMS has been able to develop this brief overview of the legal, medical use of stem cells in Mexico. As a professional medical society dedicated to patient safety through strict evaluation of protocols and rigorous oversight of clinics and faculties in sell-based medicine, we feel it is critical to provide our members information so that we can assist patients in making an informed healthcare decision.  


This overview is important because it is the first time that any group has attempted to collect the regulations for Mexico into a single document. 


We hope to use this model with other countries to provide greater transparency and oversight to this promising field.


Stem Cell NEWS

Panamanian-US Scientific Research Supports Using Fat Stem Cells to Treat Rheumatoid Arthritis 

A Panamanian-led, multidisciplinary research team has published the first description of non-expanded fat stem cells in the treatment of rheumatoid arthritis patients. "Autologous Stromal Vascular Fraction Therapy for Rheumatoid Arthritis: Rationale and Clinical Safety.

IU doctors land large grant for adult stem cell research 

An announcement involving cutting edge research of adult stem cells has doctors at Indiana University excited. The doctors, Dr. Mike Murphy and Dr. Keith March, have been included in a $63 million National Institutes of Health project nabbing spots the Cleveland Clinic and Vanderbilt lost and patients here will benefit from.

FDA approves stem cell trial for dry AMD

The US Food and Drug Administration has authorised the initiation of a Phase I/II clinical trial of US company StemCells' purified human neural stem cells (HuCNS-SC) for the treatment of dry age-related macular degeneration (AMD).

Bioethics Backlash

Bioethicists debate how to remain impartial as a bioethics journal editor joins a company that peddles unproven stem cell therapies.

Editor’s move sparks backlash 

Bioethicists are forced to consider their purpose as leading practitioner joins controversial stem-cell company.

Medical Board Moves to Regulate Adult Stem Cell Use 

The Texas Medical Board approved a tentative policy regulating the use of adult stem cells, the experimental therapy Gov. Rick Perry drew criticism for undergoing for his ailing back last year.

Stem Cells, FDA, and the Edge of Science: Three Expert Viewpoints

Regenerative Medicine Back on Fast Track

After decades of controversy and frustratingly slow progress, the stem cell field seems poised for breakthroughs in a range of diseases. One by one, obstacles such as tumorigenicity of embryonic stem cells and immune rejection of allogeneic transplants are giving way to focused study and innovation.

Stem-Cell Therapy Takes Off in Texas

With Texas pouring millions of dollars into developing adult stem-cell treatments, doctors there are already injecting paying customers with unproven preparations, supplied by an ambitious new company.

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Latest Research - Bone Marrow 

Human Dedifferentiated Adipocytes Show Similar Properties to Bone Marrow-Derived Mesenchymal Stem Cells.

Mature adipocytes are generally considered terminally differentiated because they have lost their proliferative abilities. Here, we studied the gene expression and functional properties of mature adipocytes isolated from human omental and subcutaneous fat tissues. This research focused on dedifferentiated adipocytes in culture, and their morphologies and functional changes with respect to mature adipocytes, stromal vascular fraction (SVF)-derived mesenchymal stem cells (MSCs) and bone marrow (BM)-derived MSCs. 


MRI of auto-transplantation of bone marrow-derived stem-progenitor cells for potential repair of injured arteries.

This study was to validate the feasibility of using clinical 3.0T MRI to monitor the migration of autotransplanted bone marrow (BM)-derived stem-progenitor cells (SPC) to the injured arteries of near-human sized swine for potential cell-based arterial repair.


In vitro comparison of feline bone marrow-derived and adipose tissue-derivedmesenchymal stem cells.

Mesenchymal stem cells (MSC) are increasingly being proposed as a therapeutic option for a variety of different diseases in human and veterinary medicine. At present, MSC are most often collected from bone marrow (BM) or adipose tissue (AT) and enriched and expanded in vitro before being transferred into recipients. 


Latest Research - Mesenchymal Stem cells

Integration potential of mouse and human bone marrow-derivedmesenchymal stem cells.

Mesenchymal stem cells (MSCs) are a multipotent cell population which has been described to exert renoprotective and regenerative effects in experimental models of kidney injury. Several lines of evidence indicate that MSCs also have the ability to contribute to nephrogenesis, suggesting that the cells can be employed in stem cell-based applications aimed at de novo renal tissue generation.


Identification and Characterization of Mesenchymal Stem Cells Derived from the Trabecular Meshwork of the Human Eye.

Mesenchymal stem cells (MSC) have been isolated from several adult human tissues. Their propensity to differentiate into cell types of connective tissue, such as osteocytes, chondrocytes and adipocytes, suggests that MSC may function as a reserve of progenitor cells that repair and maintain healthy adult tissues.


Dexamethasone has variable effects on mesenchymal stromal cells.

Background aims. Dexamethasone (Dex) is a potent synthetic member of the glucocorticoid class of steroid drugs. Frequently, Dex has been used to enhance osteogenic, chondrogenic and adipogenic differentiation of mesenchymal stromal cells (MSC). Recently, Dex was applied to promote MSC proliferation, because of the rare frequency of MSC in bone marrow, and could protect the cells from apoptosis.


In vivo healing of meniscal lacerations using bone marrow-derived mesenchymalstem cells and fibrin glue.

Fibrin glue created from a patient's own blood can be used as a carrier to deliver cells to the specific site of an injury. An experimental model for optimizing various permutations of this delivery system in vivo was tested in this study. Harvested equine meniscal sections were reapposed with fibrin glue or fibrin glue and equine bone marrow-derived mesenchymal stem cells (BMSCs).


Human mesenchymal stromal cells improve scar thickness without enhancing cardiac function in a chronic ischaemic heart failure model.

Few data address the role of human mesenchymal stromal cells (MSCs) in the management of chronic ischaemic heart failure. We assessed their effect in immune-deficient animals. MSCs were cultured from bone marrow of human volunteers. Non-obese diabetes severe combined immunodeficiency (NOD/SCID) gamma null mice were randomly assigned to intramyocardial injection of human MSCs or phosphate-buffered saline 4 weeks after induction of acute myocardial infarction (MI). 

News from the ICMS

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Spotlight on Adipose

miRNA expression profile during osteogenic differentiation of humanadipose-derived stem cells.

Human adipose-derived stem cells (hADSC) are capable of differentiating into an osteogenic lineage. It is believed that microRNAs (miRNAs) play important roles in regulating this osteogenic differentiation of human adipose-derived cells, although its molecular mechanism remains unclear. 


Characterization of human adipose-derived stem cells and expression of chondrogenic genes during induction of cartilage differentiation.

Understanding the changes in chondrogenic gene expression that are involved in the differentiation of human adipose-derived stem cells to chondrogenic cells is important prior to using this approach for cartilage repair. The aims of the study were to characterize humanadipose-derived stem cells and to examine chondrogenic gene expression after one, two, and three weeks of induction.

Clinical Applications And Biosafety Of Human Adult Mesenchymal Stem Cells.

Mesenchymal Stem Cells (MSCs) are a population of adherent cells that can differentiate into mesenchymal lineage populations (cartilage, bone and fat tissue). In addition, they seem to be able to differentiate also into a broader type of lineages other than the original mesodermal germ layer. 

Transplantation of an adipose stem cell cluster in a spinal cord injury.

We investigated whether transplantation of a three-dimensional cell mass of adipose-derived stem cells (3DCM-ASCs) improved hind limb functional recovery by the stimulation of angiogenesis and neurogenesis in a spinal cord injury. In-vitro experiments confirmed that 3DCM-ASCs differentiated into CD31-positive endothelial cells.


Soft tissue repair is currently limited by the availability of autologous tissue sources and the absence of an ideal soft tissue replacement comparable to native adipose tissue. Extracellular matrix (ECM)-based biomaterials have demonstrated great potential as instructive scaffolds for regenerative medicine, mechanically and biochemically defined by the tissue of origin.


Short-term Exposure to Tumour Necrosis Factor-alpha Enables Human Osteoblasts to Di rect Adipose Tissue-Derived Mesenchymal Stem Cells into Osteogenic Differentiation.

Tumor necrosis factor-α (TNF-α) is one major inflammatory factor peaking at 24 h after bone fracture in response to injury; its role for bone healing is controversial. The aims of this study were to investigate whether the duration of exposure to TNF-α is crucial for the initiation of bone regeneration and to determine its underlying mechanism(s).


Adipose-derived stem cells promote peripheral nerve repair.

Recent evidence suggests that the implantation of bone marrow-derivedmesenchymal stem cells improves peripheral nerve regeneration. In this study we aimed to investigate whether adipose-derived stem cells (ADSCs) can be used for peripheral nerve repair.


Transdifferentiation of human adipose-derived stem cells into urothelial cells: potential for urinary tract tissue engineering.

Autologous urothelial cells (UCs) provide a cell source for urinary tissue engineering because they can be used safely due to their lack of immunogenicity. However, these cells cannot be harvested under the following circumstances: malignancy, infection and organ loss, etc. Humanadipose-derived stem cells (HADSCs) possess the traits of high differentiation potential and ease of isolation, representing a promising resource for tissue engineering and regenerative medicine. 


Comparing the biological characteristics of adipose tissue-derived stem cells of different persons.

Scientists have found that cell sex is a variable that considerably influences the regeneration abilities of muscle-derived stem cells'(MDSCs) in mice. This research tries to find out whether the cell sex or cell age(the age of donor) will influence the biological characteristics of human adiposetissue-derived stem cells(H-ADSCs).


Autologous adipose tissue-derived stem cells induce persistent bone-like tissue in osteonecrotic femoral heads.

Osteonecrosis, also known as avascular necrosis, of the femoral head is a debilitating disorder that commonly affects 30- to 50-year-old individuals. Currently, definitive treatment is limited to total hip replacement. However, recent studies have demonstrated bone regeneration in the femoral head after the infusion of bone marrow-derived mesenchymal stem cells. 

Fat pad-derived mesenchymal stem cells as a potential source for cell-basedadipose tissue repair strategies.

Mesenchymal stem cells are able to undergo adipogenic differentiation and present a possible alternative cell source for regeneration and replacement of adipose tissue. The humaninfrapatellar fat pad is a promising source of mesenchymal stem cells with many source advantages over from bone marrow. It is important to determine whether a potential mesenchymalstem-cell exhibits tri-lineage differentiation potential and is able to maintain its proliferation potential and cell-surface characterization on expansion in tissue culture.

Human adipose-derived mesenchymal stem cells: serial passaging, doubling time and cell senescence.

Adult adipose-derived mesenchymal stem cells (AD-MSC) are very interesting to our research group because they are easy to harvest, they are abundant in humans, and they have potential clinical applications in autologous cell therapy for disc degeneration. 


Current status of human adipose-derived stem cells: differentiation into hepatocyte-like cells.

The shortage of human organ donors and the low cell quality of available liver tissues represent major obstacles for the clinical application of orthotropic liver transplantation and hepatocyte transplantation, respectively. Therefore, worldwide research groups are investigating alternative extrahepatic cell sources. Recent in vitro studies have demonstrated that mesenchymal stem cells(MSCs) from various sources, including human bone marrow, adipose tissue, and umbilical cord, can be differentiated into hepatocyte-like cells when appropriate conditions are used. 

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Currents in Cell Medicine is a monthly publication from the ICMS. 


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